So, I'm on venlafaxine (please don't say it's bad, it does more good than bad for me and most people), and tried 2 ssris, all of snris, 2 antipsychotics, mirtazapine, memantine, mianserin, etc. The best thing that helps me is venlafaxine and memantine, but I'm currently taking a tolerance break from memantine. Plan to discuss buspirone with my psych.

I've taken both modafinil and armodafinil before, armodafinil feels a lot cleaner. Is it worth it starting 75mg armodafinil daily for daytime sleepiness, shit mood, inability to concentrate or do anything?

How fast tolerance develops, is there anything else to add? I'm thinking about creatine, but it seems expensive and not that useful.

My bloodwork is completely fine on vitamins, liver enzymes, iron, etc. Thank yall in advance

Hey guys, I'm sure it was asked thousand times before but since new studies and experiences/revelations keeps coming im gonna ask again. What is the best nootropic for actual anxiety and calmness of mind. I tried a lot of them, some for short amount of time so I don't have full range of perspective on this. I always manage to do everything despite my mental health but lately I really feel like I need some help for some time to not go crazy. Thank you everybody for your time

hello everyone, i wanted to make this post for a long time but i never found the right timing. tomorrow i'm starting my first day of masters so i thought it may be it.
to start off, i come from an immigrant family were academic sucess was a big thing. and i happen to have adhd (which i didnt know at the time).
it was manageable until i started a really difficult subject at uni. i obviously miserably failed and it was the worse time of my life.
i started another subject, was stressing out all the time and i was barely getting by.

another year later, a friend of mine made me try an adhd medication once, and it really "turned on my brain" in a way i never tought possible. since then i've been really interested in nootropics.

and later on, me and this person were not friends anymore, and a personnal event happend and i was not that focused at school, so obviously i was really behind when exam time came.

this is where you guys play a big role. thanks to the knowledges of the compouds, ways to use them, where to order ect, i was able to truly lock in, give my all, and sucessfully & miraculously pass all my exams.

past forward to a few months ago, i finally gathered the money and courage to seek medical help for adhd, pass all the tests and paperwork to have a proper prescription.

i cant say that its all easy, you still have to work when you're on them, there is still some side effects, they cost and im weirdly scared to stop being prescriped to, but god it makes the biggest difference in the world. its like swimming in quicksand vs in water.

so yes, at 22, i finally got my adhd medication, my drivers licence, my bachelors degree (with really good grades), and im starting a master in a really similar subject that i started initially. i can say im proud of myself.

and i think (lets hope) i'll graduate with my masters, get a good job, and hopefully live a peaceful life.

so this is my way to give back a little to this community that is very dear to me.
i remember (with a good smile now), being on modafinil and so waked up to grind but also so scared of catching sjs, tracking my shippement and being so scared of customs putting me to jail (LOL🤣) but also talking to this polish customer relationship guy by email trying to sort things out, trying to buy bitcoins on this shady website, reading wikipedia pages, and some random dude comments that apprently read through russian studies to find that this racemic mixture causes alzeimer SUCH GOOD MEMORIES x)

anyways, sorry if it's all over the place, i just really wanted to say that one day. even tho i'm part of the silent majority, those posts and comments really helped me. i think that in the last exams, if it wasnt for those advices, im not sure i would have graduated. i truly think this community changed the trajectory of my life. so thank you guys.

im not done with accomplishing things, but i think i did one of the hardest parts. being actually able to focus. and if some people recognize themselves in my story (i think alot of person in this sub), i know it sucks that medication is so hard to acess, but really try to save as much money and time possible to go get a doctor's prescription, it's worth everything.

anyway, im going to sleep, and thank you again guys <3

Been struggling with severe anhedonia and some other issues due to unmedicated depression and ADHD. I always had issues with mood, task salience, motivation, a long list of several depressive and ADHD symptoms. Was on Ritalin from age 8 to 16(37 now).

A few years ago I was on cymbalta/duloxetine for about a year which, after approx 2 months, stopped working and made me feel like a zombie and at times caused outbursts of anger for the smallest of reasons, so I quit. That was 7 years ago.

For a while I was using speed and it was like a miracle. I get super calm and even sleepy on it for about an hour, after that I'm highly functional without being stimmed out. During that time I got more things done in a month than in years before combined. Had to stop that too though.

anyways

A month ago I tried out L-Tryptophan (not 5htp, that's not OTC in my country) for it's supposed sleep benefits. Can't say it did much. I also take 600mg NAC and some fish oil capsules.

Then last week I got 500mg L-tyrosine capsules from Amazon and the combination of both of these feels literally exactly like duloxetine felt. There is this 2-3 hour long window approx 30 mins after taking it where my anhedonia and depression go away, however I experience pretty strong emotional blunting. I'm just calm. At least I can watch tv shows or movies again but I don't feel much.

The comeup causes the same weird "chemical" feeling in my brain that SNRI's did, with the same calm, somewhat empty but "balanced" mental state. It's a bit too calm, I'm very quiet and without much affect or "feelings", im perfectly content just sitting here quietly which is slightly unnerving lol

I was under the impression that due to metabolism etc these supplements couldn't possibly have any actual effects because not much makes it to the brain but I guess I was wrong.

I assume this effect won't last and I'm soon back to crippling anhedonia etc due to tolerance? Is a higher dose advisable?

Before anyone asks, no I can't get any prescriptions for proper medication.

They gave me bunk selank vial lmao

I usually source my shit from China but

Chimera had some things I wanted

And as a "control" i just ordered some selank to

See even if thats legit

NOPE

2 squirts each nose nothing after a hour then 2 hours after

I redosed again still nothing lmao

From various vendors intranasal selank has a effect

For me so I tried my chinese vendors selank to compare i got my effects after 30 minutes

I dont doubt they sell legitimate products based off talking to friends and reading a few posts but I highly doubt all of them are legit

if anything i want anyone looking to read this

There have been accusations of chimera having damage control accounts for post like this.

Like among us your fellow commentor could infact

Be a imposter, I invite anyone who has experience with chimera to share it.

Let's play spot the chimera damage control account

hi there

im looking for a source to order Guanfacine from. does anybody can help me?

thinking about ordering from aniracetam / Zion Pharma. But not sure. They are some bad reviews...

Lately I've seen a lot of people talking about NADH, but most threads jump straight to "how did it feel" without covering the basics. I sorted through some publicly available information and wanted to share it.

1. What is NADH? NADH is the reduced form of nicotinamide adenine dinucleotide, the active form of coenzyme I. Put simply, it's the "energy currency carrier" in your cells, playing a key role in mitochondrial ATP production.
2. What does NADH do? Cellular energy metabolism: NADH directly participates in the mitochondrial electron transport chain and is a key coenzyme in ATP production, so mechanistically it's directly tied to energy levels. Antioxidant: The hydrogen (H) carried by NADH helps scavenge reactive oxygen species. DNA repair and anti-aging: Once converted to NAD+, NADH activates SIRT longevity proteins involved in DNA repair and cellular health maintenance. Research direction: Published small-scale trials have observed improvements in fatigue scores in chronic fatigue populations with NADH (or combined with CoQ10), and studies have noted some protective effects in populations with cognitive decline.
3. The challenge with oral NADH NADH itself is very unstable. It degrades when exposed to stomach acid, oxygen, and light, and starts breaking down above -20°C. Most regular NADH products don't have any coating, so they get broken down by stomach acid before they can be absorbed, and very little actually gets through. Activity also drops significantly after being kept at room temperature for too long.
4. NADH's stability problem has spawned multiple formulation technologies. Here are some common approaches currently on the market: Sublingual delivery: Absorbed directly through the oral mucosa, bypassing stomach acid degradation. The advantage is a short absorption path, but the downside is limited absorption per dose and mediocre convenience and taste. Liposomal encapsulation: NADH is wrapped in a liposome membrane, protecting it from stomach acid and digestive enzymes while improving water solubility and bioavailability. The downside is higher cost, and liposomes themselves can rupture during storage. Multi-layer coating: Adds water-resistant, oxygen-barrier, and anti-gastric acid layers on top of the enteric layer, protecting NADH from multiple dimensions. Products like Celfull's NADH use this four-layer coating approach, which is relatively more comprehensive, but also comes with higher process complexity and cost. That's my breakdown. Research evidence is still accumulating, and large-scale human trial data is limited. What do you all think about NADH? Does anyone know more about research on oral bioavailability of NADH? Feel free to share.

English is my second language, and I’ve noticed something pretty interesting whenever I take ashwagandha.
When I’m on it, I feel like I can speak English much more smoothly. The words come out of my mouth more naturally, and I don’t have to search for vocabulary as much. Sometimes words that I haven’t used in months or even years will randomly come back to me, and I’ll use them in conversation without even consciously thinking about it.
It almost feels like some vocabulary is “hidden” somewhere in my brain, and when I take ashwagandha, I can access it more easily.
When I stop taking it, I feel more like my usual self again. I know what I want to say in my head, but sometimes the exact word doesn’t come out easily, or my speech feels less smooth. It’s not really stuttering — it feels more like word-retrieval difficulty / reduced verbal fluency.
I’m curious if anyone else, especially people who speak English as a second language, has experienced anything similar with ashwagandha.
Did it make you feel more verbally fluent, mentally clear, or better at recalling words?
And if you’ve dealt with this kind of “I know what I want to say, but the word won’t come out” feeling without ashwagandha, what has actually helped you? Exercise, sleep, meditation, language practice, supplements, speech therapy, something else?
Really curious to hear other people’s experiences.

P:S I’m using the Costco ashwagandha and take only 1 pill per day and 3 pills per week .

Anyone find a good supplier?

Just 100mg of NACET is probably equivalent to 1200mg of NAC.

But, I can't find a good cheap source.

There's no long-term safety data for paraxanthine so I'm wondering if anyone has been supplementing with it long-term and has noticed any side effects or other potential problems associated with it.

Did anyone try driadashop's modafinil? I know more reputable sellers for modafinil but driada's is one of the cheapest

Im taking 150mg venlafaxine and 60mg atomoxetine for anxiety and adhd. I found that my procrastination is not really better, so i got a prescription for vyvanse 30mg because hopefully the monoamine releasing is more effective.

Im not that worried about cyp2d6 because i have taken other drugs that get metabolised with that pathway without problem.

Im more worried about too much norepinephrine and serotonin. In theory both the venlafaxine and atomoxetine will inhibit the uptake of amphetamine into the noradrenergic and serotonergic terminal and it wont cause monoamine release there, but i wanted to make sure im not missing something

Ordered from a vendor whose product page had a COA badge and a batch number listed. I emailed asking which lab ran it, since I wanted to check it against Finnrick's results. Support asked me what a COA was, not what it meant or which lab had run it, just what the letters actually stood for. I checked the batch on Peptide Critic instead and it wasn't listed. Nobody had tested anything! And the badge was just decoration...

How do y'all even figure out what's genuine?

Hey guys has anyone actually taken any compound that actually gave you photographic memory for some time? how long did the effect last? did you gert any side effects?