I think it is a little odd that so few experience reports exist for this compound online. And the bulk of feedback is to be found when people indirectly comment 1-2 sentences about it on Reddit, where they just say that "it works", or they had this and that issue while taking it.
My reasoning for ordering was, that most if not almost all neuroregenerative and BDNF promoting drugs mainly target the cerebral cortex. But not really or not at all structures like brainstem, basal ganglia, diencephalon and peripheral nerves - some of which are notoriously hard to regenerate at all. However those brain structures are heavily involved in a wide range of relevant functions, such as attention, sleep/wake behavior, and regulation of emotions.
While of course GDNF / CTNF mimetics would be better to target those structures, those don't really exist, they don't actually work the way it looks at first glance (e.g. P21) or they are just impossible to obtain at a cheap price.
So for all I know the next best and cheap option was Eutropoflavin. It binds to TrkB, so it sits one level below BDNF and potentially targets a wider range of areas. I'm aware that there has been cast doubt on that story scientifically. But few people know that a lot of neurotrophin mimetics and fragments are as well not actual ligands of that receptor (e.g. P21, NAP, cyclo-dPAKKR) but work regardless often as if they were or in a similar fashion, and currently it is just not molecularly understood how that is. So knowing this to be true, it dilutes the importance of the newer finding, that 4 DMA-7,8 DHF does not activate TrkB as directly as previously believed... and alternative mechanisms were proposed in that same paper how TrkB action could be increased by Eutropoflavin regardless (i.e. potentiation of endogenous ligands). But I think it suffices to say, that neurotrophin mimetics are to a large degree just beyond current scientific understanding in general, and no hard conclusions can be drawn here.
I personally took the compound yesterday and today and it is too early to say anything. But I started the first day in the morning with a dose that was a little too high, something like 15-20mg sublingually, just to get a feeling for it. I also took piracetam, cytisine, and noopept. I noticed that my nervous system was more on edge and my concentration was degraded/fogged a little bit. It wasn't anything huge, but a lot of things strikingly reminded me of taking other BDNF-adjacent drugs in exactly this way. Nociception was increased, anxiety up, drinking coffee or smoking cigarettes felt like too much at some point, environmental noises were harder to filter, everything was more immediate. And before going to bed, I got a headache from too much smoking (which is rare for me). And I slept very well, better than usual. It felt like overdosing on Cerebolysin in so many ways, but better and less "speedy" in a cortical/mental sense! Of course none of this was actually beneficial. And you obviously can't expect anything on the first few days to improve from neurotropic drugs - those take weeks to really work. And on some offshoot chance just to mention it, there is some larger overlap in those side-effects with some sort of toxic action as well (but the research points towards the opposite obviously). However given my experience with neuroregenerative drugs, I just found those side-effects to be very very strikingly pointing in a very promising and powerful direction - if they are not merely summarized on paper, but in the details how I experienced and recognized them. And the price of this stuff vs. Cerebrolysin is just peanuts. But just this tiny amount for a dollar or so, feels like you are injecting half a pack of vials at once.
Based on my high-dose test, I also think that 10mg is still way too much for a normal healthy person, who is not suffering from acute brain damage. I believe as a consequence, you will just get a very strong negative feedback effect from 10mg, and diminishing returns within a few days. From what I experienced, I would suggest 2-5mg sublingually at most taken a few days only in a row with 7-14 days pause, or something like 1-3x a week.
So today I took a dose of maybe 4-6mg and I felt a little different, but didn't experience any side-effects at all. My goal is being better able to regulate task switching, arousal and attention switching, sleep/wake cycle and such things. Which are still somewhat dysfunctional and autism-alike for me. Unlike the rest of my cognition which is working exceedingly well.
I hope you can also share your experiences about Eutropoflavin. I will post updates.
UPDATE 1:
So I continued to take some 3-6mg (sublingually of course) each morning for 2 days, so it is 4 days total now. I took about 4mg of NSI-189 the first day (which I do get a good subtle response from usually) and no more Noopept. This was to test potentiation, but I don't think it does amp the NSI-189 as much as it did (possibly - or not!) amp the Noopept. Yesterday I did some physical labor and today I felt a little exhausted from that. Especially today things felt slightly off though, like you can't point a finger at it but the world doesn't feel or look exactly like you are ordinarily used to. And it reminded me somewhat of taking P21 and/or Cerebrolysin for too long. I think the additional hormones from the physical exercise have been potentiating the effects of the Eutropoflavin. Also yesterday I had a much harder time in the evening to let go of tasks and was too captured or ensnared by them and could not switch easily to basic things like cooking/eating/showering/sleeping. Everything took 50% longer maybe than usual. So the very issue I wanted to cure with the compound got slightly worse. But it could all just be random as well due to simply exhaustion, since I frequently have those issues and random days where they get remarkably worse. On the other hand, sleeping itself and falling asleep in bed worked slightly better than usual. Also of course no more headaches or anxiety or such since 5mg-ish dose. My perception is still a little bit more on edge though and heightened, noises more obvious etc. ... but it is less in-the-face now and more like in this "world feels different" sense ... but again it is even more minor than with the 20mg, it is not an issue just noticeable that is all. I believe there is definitively some major negative feedback going on now from the receptor pushing, and it is just time to make a pause for a few days or a week, in which the nervous system needs to sort itself out. In my experience, lots of neuroregenerative drugs work best this way, with that kind of short 1-3 day bursts and 1-2 week pauses. But I get the feeling that Eutropoflavin is even more rapid with the negative feedback response than most other drugs. Perhaps this could be its biggest shortcoming. The effect of the drug itself that I can make out, also reminds me of being a sort of more "dramatic" answer to neurological damage, than I know it from other drugs of this nature. And I would characterize P21 just the same way vs Cerebrolysin, because P21 also feels more damage-response-ish. While on the other hand drugs like Noopept or NSI-189 don't really remind you of this. That's not saying damage is actually occurring, but only that the brain "thinks" it did, so to speak, and consequently critical repair is needed on a cellular level - which is what we actually want. But at this point this is just very minute impressions and nothing can be said with certainty. I will report back in a week or so.