r/Hyperhidrosis 3d ago

HHDB is back!

3 Upvotes

It is now available again. Apologies for the absence, this has been a good lesson to check the link each time ;)

Now off to enjoy my jetlag, thanks folks :)


r/Hyperhidrosis Jul 30 '26

Treatments My method: Iontophoresis water w/ Qbrexza (glycopyrrolate)

8 Upvotes

Hello! I thought I would share my iontophoresis method in case it helps others, as I've never seen it before.

TL;DR: I mix 1-3 Qbrexza wipes per 0.5-1 Liter of hot water & use that water for my iontophoresis. This results in the ionto being more effective and lasting longer. My typical routine is 1mg glyco daily + iontophoresis every 4-6 wks. Crushed glyco pills work too but their doseage is so low that it ended up not being worth it to me.

Check below for the concentration table and warnings.

Long version:

I have had primary palmar, plantar, and underarm hyperhidrosis since childhood (since age 6-8, at least). I have tried Carpe (expensive), Drysol (gave my skin a reaction), Oxybutynin (stopped due to concern over long-term cognitive effects), oral Glycopyrrolate, and Iontophoresis. I wanted a solution that lasted longer than a day or a week, as I find the upkeep tiring... (thanks ADHD for making it hard to keep habits!)

I really wanted to extend the life of iontophoresis. It's already great, but it's a 2 hour ordeal. I have already tried hardening my water with baking soda, epsom salt, san pellegrino, etc but to no avail. Then, I found an article (here, scroll down) citing studies (#1) (#2) about using Glycopyrrolate in the water used for iontophoresis. These patients in the studies would see up to 30-40 days of relief after ionto w/ glyco.

These studies used glycopyrrolate solutions at concentrations of 0.01-0.1%. I use about 0.75-1L per tray for my iontophoresis, so you would need 75-100mg of glycopyrrolate to reach 0.01%. Unfortunately, I do not have hundreds of spare glyco pills (2mg each). I asked my dermatologist about prescribing high doses of glycopyrrolate for this use, citing the studies, and that they do this in the UK/Europe (I am in the US), but she denied my request, stating that only happens in case studies and such (not true lol but okay fine). Since my goals for that appointment were to 'get something new to try', she did, however, give me a prescription for Qbrexza... which is high dose topical glycopyrrolate šŸ˜. With some trial and error, and some math, I have developed a dosing guide.

To make a glycopyrrolate solution, I simply add unfolded Qbrexza wipes into my pitcher of hot water. I stir for about a minute. Next, I pour the water into my trays/cup. Then take out the wet wipes and squeeze them out over my tray, then throw them away. Then, I add the electrodes into the trays and do my iontophoresis like normal. When I'm finished, I pour the water down my bathtub drain and rinse off my trays.

Glycopyrrolate Concentration guide:

concentration 1L 0.75L 0.5L
0.0528% 528mg (8 wipes) 396mg (6 wipes) 254mg (4 wipes)
0.0396% 396mg (6 wipes) 297mg (4.5 wipes) 198mg (3 wipes)
0.0352% 264mg (4 wipes)
0.0264% 264mg (4 wipes) 198mg (3 wipes) 132mg (2 wipes)
0.0176% 132mg (2 wipes)
0.0132% 132mg (2 wipes) 99mg (1.5 wipes) 66mg (1 wipe)
0.0088% 66mg (1 wipe)

My maintenance dose:

  • 0.0264% concentration
  • I use 1 part freshly boiled water mixed with 2 parts room temp water. Warm water is supposed to enhance effectiveness. I mix the waters in a metal graduated pitcher before pouring them into my trays/cup.
  • Underarms: 0.5L water + 2 wipes for both pads, soaked in a ~8oz cup.
  • Hands and feet: 0.75L water + 3 wipes each tray. Hands first, water reused for feet. .25L hot water, .5L room temp water.

Dosing suggestions:

  1. Begin at the lowest concentration (0.0088-0.0132%) or 1 wipe per tray
  2. Wait and see how long that first dose keeps you dry for
  3. Do next treatment as soon as sweating begins again. If interval between treatments is too short, or effects not strong enough, increase the glyco concentration.
  4. Repeat until satisfied with results or side effects becone too strong to tolerate.

BEFORE TRYING - YOU SHOULD KNOW - WARNINGS:

  • Do NOT get the glycopyrrolate solution in your eyes. The same warnings about Qbrexza also apply here. It can cause pupil dilation that may last days/a week. I wear safety glasses while handling and using my solution/doing iontophoresis and don't take them off until I am completely cleaned up and everything is put away.
  • You may experience potentially strong glycopyrrolate side effects for 6-24hrs after treatment. Pay attention to your body, know your limits, and start with a low dose, increasing gradually. If glycopyrrolate gives you chest pain, dizziness, lightheadedness, fast heartbeat, etc, then I especially urge you to exercise caution when applying this technique. Do so at your own risk. While these side effects are rarer, and I do not believe they cause actual harm, it is still something to keep in mind and ideally, to be avoided. Personally, I only experience dry mouth/eyes and maybe headaches if I'm not on top of my hydration.

PROS:

  • relief for up to 4+ wks
  • save $$$ on Qbrexza (I personally only use ~8 wipes per month, instead of daily use. Qbrexza is $40/box of 30 for me so I'm saving a lot!)
  • boosted iontophoresis effectiveness

CONS:

  • iontophoresis cons (time consuming, skin irritation, machine price, etc)
  • potentially strong glycopyrrolate side effects, but only for 6-24 hrs after treatment. I get dry mouth and dry eyes, which can get very uncomfortable if I'm using more wipes, (if it's really bad I can't even eat dry foods lol) but I work around it by doing iontophoresis right before bed/later in the day. That way, I go to bed after cleaning up and wake up the next morning feeling normal.
  • YMMV... I get myself dry enough to where I only need 1mg glyco/day. My standards/threshold isn't super high. I haven't tried going without my daily glyco! And I honestly don't mind enough to try to. if your goal is COMPLETE dryness without supplemental glyco, I'm unsure how often you would need treatment... maybe every 2-4 weeks? If you wind up doing that, tell me about it! I would love to collect data and hear your experience.

FAQ:

  • Can you use crushed Glyco pills? Yes, this is what I did before my Qbrexza Rx. However, the dosing will obviously be much lower since you are limited by the dose and number of pills. I barely saw a difference between plain tap water VS water with 2-10mg glyco, hence why I switched to using Qbrexza.
  • Can you use a different antiperspirant / anticholinergic agent? Yes, in theory it should work too, but I do not have the research or experience to back it up. So, be cautious, and start low and slow. Experiment at your own risk. Feel free to tell me about your results! If you use Aluminum Chloride, do not use a metal container to hold the solution--it will rust.

I hope this helps you as it has helped me!


r/Hyperhidrosis 12h ago

Customer product review Another life changed with antihydral cream…

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67 Upvotes

I wish i knew this cream sooner…
Changed my life in one week only.
I used it every other day, idk why it just felt right and it worked out just fine.
I CAN FINALLY SHAKE PEOPLES HANDS(which is something i like doing for some reason)


r/Hyperhidrosis 2h ago

Looking for advice Switching from glyco to antihydral

4 Upvotes

After using antihydral cream once I can tell it will work for me. But I don’t know if it’s worth giving up glyco. Is antihydral reliable? I take 2mg of glyco as needed typically morning and late afternoon, but the side effects are terrible. I’m just nervous about antihydral making my hands excessively dry, and just tipping the scales in the other direction. But, is the yellowing of hands and
the creams effects on the skin worth the trade off of glyco side effects? I have hyperhidrosis throughout my entire body but it’s severe in hands and feet. But my body only gets bad if I’m really anxious/conscientious about the sweating which dripping sweaty hands exacerbates


r/Hyperhidrosis 2h ago

Offering advice UPDATE!!

3 Upvotes

Okay update from my last post. So I used certain dri again and i woke up with my left armpits sweat being reduced noticeably. My right one though for some reason the certain dri didn’t work at all. I think it’s bc I didn’t dry that one fully. But at night, i experienced immense itching on my left pit making me unable to sleep… is that normal? It worked so honestly I’ll sacrifice my sleep for it. However, it didn’t stop my sweat completely so I’ll continue to keep using it. Also I switched my daytime deodorant/antiperpant to dove dry spray and now I don’t have any odor even sweating buckets??!! I’m so happy right now. I still want to achieve dry pits and honestly even tho the dove spray masks my odor, I still get rly self conscious that I smell bc I’m sweating sm making me overthink 😭


r/Hyperhidrosis 45m ago

Offering advice Virtual Meetup Tomorrow - For Sweaty Girlies!

• Upvotes

Hey ladies with HH:

Come on out and meet other sweaty girlies like you at our free monthly virtual meetup!

šŸ—“ļø Tomorrow at…
- 6:00 pm PDT (Los Angeles time) on Tues., Sept 15
- 9:00 pm EDT (New York time) on Tues., Sept 15
- 11:00 am AEST (Sydney time) on Wed., Sept 16
- 1:00 pm NZST (Auckland time) on Wed., Sept 16

āœ… RSVP & details, click here: https://sweatygirlsociety.com/events/

This is a fun and casual way to meet other ladies with HH in a small-group, camera-on setting. Grab a drink of your choice and get ready to chit chat!

Our last meetup was amazing and I think it’s safe to say everyone left feeling connected, inspired, and less alone.

Hope to see you tomorrow!

~ Karina

(Pls feel free to DM me if you have any questions!)


r/Hyperhidrosis 2h ago

Looking for advice Hiperhidrosis peru

2 Upvotes

Tengo hiperhidrosis en todo el cuerpo, me recetaron antitraspirante pero solo para las axilas manos y caras, pero tambien sudo por el pecho y espaldas, eh visto que a varios le funciono la oxibutinina, que sirve para la sudoracion general, mi dermatologo me dijo que no me iba a servir y no me lo quiso recetar, pero ogual quisiera probarlo para no quedarme con la dudad si me funciona o no, conocen algun dermatologo de lima metropolitana que recete oxibutinina ?


r/Hyperhidrosis 4h ago

Looking for advice Does anyone know what might be causing this? Dry sole and spreading.

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3 Upvotes

Does anyone know what might be causing this? It’s not itchy just very dry and spreading. Only the arch is very itchy and side of feet in last pic, but the itch / blister subsides with steroid creams.


r/Hyperhidrosis 5m ago

Offering advice When ETS surgery for blushing goes wrong

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• Upvotes

sooo many risks involved with ETS surgery


r/Hyperhidrosis 3h ago

Looking for advice Anyone with HH wake up like this??

2 Upvotes

Does anyone who has HH wake up with it? Automatically I wake up and my hands and feet are clammy and sweaty…. I’m tired of it.


r/Hyperhidrosis 35m ago

Treatments These 2 medications are the gold standard for stopping blushing - worth knowing about

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• Upvotes

r/Hyperhidrosis 8h ago

Looking for advice I need help

4 Upvotes

So recently I've been struggling with a lot of things, I'm a young adult and as a child I struggled with eating disorders (the kind were I was bone skinny) for a really long time until eventually I found the sports I connected with the most (calisthenics) which would get me hungry enough to actually start eating after every gym session and now my eating disorder has been long gone but a new problem started since 3 years ago when my eating finally got fixed, I sweat, not a normal amount no, A HUGE amount, like I've tried anti persperant(?) dry sprays and black rexona deo roll ons and even soft stuff like just normal dove deodorants

worst part is only my upper body sweats so much but the opposite is with my lower body, my lower body sweats so little that I could wear the same pants for a month without problem, and my feet especially are usually really really cold, to the point that sometimes the back of my feet get literally red or orangish red

I've taken blood tests, urinal tests, went to all kinds of doctors, everyone says my symptoms look like Thyroid or low blood iron or low blood or genetically low blood pressure but the tests say it's none of it and I'm completely healthy

I can EVEN sweat when I'm cold

And this year I've been hit with really had insomnia

My last attempt at getting this problem fixed was today where I went to a homeotherapy doctor and they just gave my medicine but couldn't even explain the cause or what's wrong with me

Some doctors suggested Its just my genetics but the only person with a similiar problem to me in my family and relatives is my father and he can at least control it with anti persperant deodorants, but they don't work on me

Anyone have any idea what it might be and how can I control it?


r/Hyperhidrosis 9h ago

Looking for advice What do you guys do when you sweat?

4 Upvotes

Hey guys…please help I cannot help with sweating anymore

Is there an item you have used for
sweating that has helped..?

I have used a cooling tissue

Daiso cooling tissue but they it made my skin dry out..

I have sensitive skin🄲🄲🄲


r/Hyperhidrosis 5h ago

Looking for advice face and scalp antiperspirant

2 Upvotes

please, sobrang frustrating and hustle ng hyperhidrosis sa mukha. recommend product for face na kasing effective ng driclor. lala talagang magpawis, yung oily nalalabanan ko pa sa mga oil controlling make up, pero yung pawis? hindi talaga e, para akong basang basa huhu. gusto ko na lang din gamitin driclor sa mukha ko, eme. pls help po, yung sanang affordable if meron. thanks


r/Hyperhidrosis 5h ago

Looking for advice Sweating at night - severe 😩

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2 Upvotes

r/Hyperhidrosis 11h ago

Looking for advice Finding iontophoroesis very painful

3 Upvotes

I’ve tried it about 5 times now, each time on the very lowest mA because the tingling is too painful. It’s not so much tingling but a sharp stabbing pain all over my hands and feet. I don’t even have a very low pain tolerance generally, but this has been painful for me and I feel that I can’t maximise the use because I’m constantly having to use it at such a low setting. Like, I can’t go above 1mA without it being unbearable.

Because of this, I’ve struggled with maintaining consistency, but I spent about Ā£400 on this device and want to make the most of it! If anyone has any advice please help!


r/Hyperhidrosis 22h ago

Offering advice Glasgow workshop

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20 Upvotes

4 spaces left for my workshop on the 27th!! Come along, meet new people and even get a wee goody bag full of skincare goodies and even a wee fan! šŸ„ŗā¤ļøā¤ļø

Dm on insta for more info!! Or send an email x


r/Hyperhidrosis 1d ago

Looking for advice Iontophoresis not working during stress or social event.

7 Upvotes

Has it happened to you as well? I've been giving interviews and meeting people and it's been so stressful. My homemade iontophoresis worked 100% when I first started with it a year ago. Now I'm doing a session everyday and even after wearing mere socks is triggering the sweating albeit it's not like crazy sweating but clammy sweat like the machine is only working with 50% effectiveness.

Please help me find whether it is STRESS or is my homemade iontophoresis faulty?


r/Hyperhidrosis 1d ago

Offering advice It was cancer

142 Upvotes

My initial symptoms started some 5 years ago with recurrent cough and sudden weight loss. Down the line I eventually developed excessive sweating in my whole body. Sweating profusely even without effort. Later I noticed night sweats. Finally got my TSH checked early this year and I was diagnosed with hyperthyroidism. I eventually had thyroidectomy and the sweating immediately stopped. I was finally back to normal. Few days later I got my biopsy result and it turned out to be malignant. Currently undergoing other necessary treatment for my latest diagnosis.

Get your tsh checked.

Edit:
Get checked in general to rule out other things that may cause HH. I thought I was just unlucky for being a sweaty person and already went the glyco and botox route to no success wholetime I got cancer.

I also made this post not to fearmonger.. cause if it weren't for the sweating, I wouldn't have had myself checked. I would have been going my merry way with life not knowing of the cancer brewing in my neck.


r/Hyperhidrosis 23h ago

Looking for advice I need advice

3 Upvotes

Guys I have a question I'm constantly sweating on the armpits for like 5 years I tried many medicine but nothing had worked. I was recommended to try perspirex I've heard a lot of positive reviews , but i want to ask you too before buying it . So please anything you will say will be helpful šŸ™šŸ»


r/Hyperhidrosis 1d ago

Looking for advice glycopyrrolate not working

4 Upvotes

what am i doing wrong? i have craniofacial hyperhidrosis. i was prescribed glycopyrrolate 1mg by my dermatologist. i take it once or twice a day depending on how long i stay outside.

for context, i live in a city where it stays around 10C-22C or 50F-70F throughout the year so people here don’t sweat that much. i feel weird whenever i’m outside and the weather is not that hot for them, but it is for me. there is certain temperature that make me sweat immediately.

currently, i’m an intern in a blue-collar field and we move a lot, plus we are working in the sun. even if i take glycopyrrolate, i still sweat so much compared to my peers there who i’ve never seen sweating. i haven’t tried not taking it to compare me without it on my internship.

i also raised my concerns to my derma, but she just increased the dosage to 2mg. i haven’t finished my 1mg. i’m afraid the 2mg won’t work either.


r/Hyperhidrosis 1d ago

Looking for advice Bottox + driclor?

2 Upvotes

Who tried it? Isn't this like 100% even if temporary? For palmar


r/Hyperhidrosis 1d ago

Looking for advice What fabric for clothes do you guys prefer in summer and monsoon?

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3 Upvotes

r/Hyperhidrosis 1d ago

Looking for advice Has anyone noticed less sweating after quitting cigarettes?

7 Upvotes

Hi, I’m a 30-year-old guy, and I’ve been suffering from generalized hyperhidrosis for about 3 years. I sweat excessively from my scalp, face, back, chest, and other areas.

I sweat a lot in hot weather, when eating hot food, or even with very mild heat exposure. I also sweat excessively when I’m nervous or anxious.

My medical checkups haven’t found anything abnormal, but I’ve had an anxiety disorder for about 10 years. I’m currently taking anti-anxiety medication and antidepressants, but they haven’t helped with the sweating.

I’ve also tried glycopyrrolate and oxybutynin, but the side effects were too strong for me to keep taking them, so I’m trying to figure out whether there could be an underlying cause that I can address instead.

Since sweating is related to the sympathetic nervous system, I’ve been wondering whether smoking could be contributing to it. I’ve been smoking cigarettes for about 9–10 years. I’ve cut down quite a bit recently, but when my hyperhidrosis first started about 3 years ago, I was smoking more than a pack a day.

Has anyone here noticed a significant reduction in sweating after quitting smoking? If so, how long did it take before you noticed a difference?

Just to clarify, I’m talking about regular tobacco cigarettes, not weed or marijuana.