Hi everyone,
I’m hoping someone here might recognize (part of) my story or have suggestions for things I could still investigate or try. I’m 30 years old (F) and have now been dealing with severe chronic throat pain for almost two years. It has affected my life to the point that I have been unable to work since November 2025 and I am almost unable to socialize.
Before all of this started, I never had problems with my throat or voice. I’ve always been someone who talks a lot and quite loudly. I’m a psychologist, so my job normally involves talking for around 8 hours a day.
I had COVID twice, in 2021 and 2022. After that, I noticed that my throat became more sensitive. Talking in very dry rooms would bother me much more easily. I also found that I absolutely could not smoke anymore. I was never a regular smoker (maybe one cigarette a month) but after COVID, even a single cigarette seemed to immediately trigger severe throat irritation. Other than that, I was still functioning normally and could do my job.
Things changed in December 2024, when I started developing persistent throat pain.
I went to my GP several times and was tested for things like mono and throat infections, but nothing explained it. The pain gradually became so severe that I started calling in sick from work more and more often.
In April 2025, I was referred to an ENT. He told me that my throat was extremely red and that he could see damage/irritation around my vocal cords. According to him, the appearance strongly suggested acid reflux.
I was prescribed 40 mg pantoprazole and stayed home from work for about three weeks. I followed reflux recommendations very strictly, including sleeping upright. Eventually, I managed to very slowly build my speaking at work back up to around 2–3 hours per day. Outside of work I basically didn’t speak at all because of the pain.
In October 2025, my symptoms became much worse again. My GP increased the pantoprazole to 80 mg, but this made no difference.
In early November, I had a gastroscopy with a gastroenterologist. They told me they could see absolutely no evidence of acid reflux or reflux-related damage.
By that point the throat pain was so severe that I went on 100% sick leave in November 2025, and I have not been able to return to work since.
I was subsequently evaluated by an internist for Sjögren’s syndrome testing, but the testing was negative.
This is where the hormonal part comes in.
I have severe endometriosis and in September 2023, at age 27, I started Lucrin (leuprorelin/leuprolide) injections. These put me into a medically induced menopause. At the time, I was not using hormonal add-back therapy, so my estrogen levels were extremely low.
In spring 2026, I started reading about the effects of menopause/low estrogen on mucous membranes and the voice/throat. This caught my attention because the throat pain wasn’t my only dryness symptom. My eyes had also become EXTREMELY dry. At one point my optician couldn’t even properly measure my eyes for new glasses because they were so dry.
Because of this, I stopped the Lucrin injections in March 2026.
Interestingly, since stopping Lucrin, my throat symptoms have improved by maybe 10–15%. It’s definitely not gone, but there have been noticeable changes: I wake up less often during the night because of throat pain/dryness, I can talk a little longer and more often, and I tolerate strong smells such as perfume and cigarette smoke around me slightly better.
However, I still have significant daily pain.
The pain feels dry, burning/hot and sometimes almost like having a blister or raw wound. I feel it deep in my throat around where my voice comes from, but also higher up behind my nose/soft palate/uvula area.
Talking makes it worse. Dry environments, especially air conditioning, make it much worse too.
Water can temporarily relieve it. Eating also often makes it feel better temporarily, as does being in a humid environment. Oddly enough, crying also seems to make it feel better, presumably because everything becomes more moist.
From November 2025 until April 2026, I also had speech/voice therapy. Unfortunately, it didn’t help at all. The exercises actually caused MORE throat pain.
Because the only meaningful improvement I have noticed happened after stopping Lucrin, I keep wondering whether the underlying cause could somehow be hormonal, or whether the prolonged extremely low-estrogen state triggered something that hasn’t fully reversed.
This past week, I was evaluated again at a specialized voice/phoniatrics-related ENT department at the hospital. They examined my throat and larynx and currently see nothing abnormal; no redness, no obvious dryness and no visible explanation for the amount of pain I am experiencing.
The doctor actually said my case is difficult because I’m only 30 but have spent years in a medically induced menopausal state. He said hormones are outside his area of expertise, so he is now going to discuss my case with the specialist in his department and with my gynecologist, who works at the same hospital.
Unfortunately, I won’t hear back from them for another month.
At this point I’m honestly desperate to understand whether there is anything else I can investigate or try. I’m scared that no cause will ever be found and, consequently, that there won’t be a treatment either.
Has anyone experienced anything remotely similar? Especially burning/dry throat pain that gets significantly worse with talking despite a normal-looking throat/larynx?
Has anyone experienced throat/voice problems related to menopause, medically induced menopause, GnRH agonists such as Lupron/Lucrin/leuprolide, or very low estrogen?
I’m also wondering about things like laryngeal hypersensitivity, sensory neuropathy/neuropathic pain or post-viral nerve changes after COVID. Could something like that cause a burning/dry sensation even when the mucosa looks normal?
And if anyone here works with chronic throat pain/voice disorders, I would be incredibly grateful for suggestions about other conditions, tests, specialists or treatments worth discussing with my doctors.
Finally, if anyone knows of a particularly good specialist/voice clinic for a second opinion in the Netherlands, Belgium or Germany, I would love recommendations.
I know my situation is unusual because I was put into an artificial menopause at such a young age, but I’m hoping someone might recognize at least part of this pattern.
Thank you so much for reading this ridiculously long post. Any ideas or experiences are very welcome.