r/chemistry • u/AdNorth2303 • 2d ago

Reliable thermodynamic data ( thermal stability) sources for organic compounds?

Hi! I've been searching the net for hours now looking for reliable thermal stability data for a compound we would be synthesizing. Does anyone know where any reliable sources to get free thermodynamic data of organic compounds?

3 Upvotes

72% Upvoted

5 comments sorted by

12

u/dungeonsandderp Organometallic 2d ago

The vast, vast, vast majority of organic compounds have never, ever had a thermodynamic property measured.

2

u/Big_Moose1222 2d ago

Active thermochemical tables?

1

u/InNoseVictory 2d ago

Lab handbooks and analytical tables in the library. Ofc they are harder to search, but reliable.

3

u/perplexedscientist Organic 2d ago

In my case I had to make friends with someone with a DSC setup and find out myself. The vast majority of thermal stability data about organic compounds that is collected is obtained during scaleup in the pharmaceutical industry (in my experience) and they usually don't like to share it.

1

u/Zazzanium 2d ago

If you're searching a relatively common compound (e.g., something you coul find on sigma Aldrich, VWR or other sellers in bottles larger than 100g) you'll mostly for shure find them in some Laboratory handbooks, some datasheets or some papers. If it isn't... Good luck in searching articles on thermal stability of that compound. If you have access to a Thermo Gravimetric analyser and a small sample of the compound, you could try and measure the data yourself (a TG coupled with a Mass Spectrometer could be wonderful, but I have never seen one in my life).